2006

Vaidisova captured her 6th WTA title at the Tier III event in Strasbourg. In June, Vaidisova made a semifinal run at the French Open, her best Grand Slam performance to date. She defeated World No. 1 and home favourite Amélie Mauresmo 6-7, 6-1, 6-2 in the fourth round and Venus Williams 6-7, 6-1, 6-3 in the quarterfinal. However, Vaidisova lost to Svetlana Kuznetsova in a tight 7-5, 6-7, 2-6; it has been noted Vaidisova was only two points away from victory several times. At the Wimbledon Championships, Vaidisova got to the fourth round before losing to Li Na. She has now advanced to the Round of Sixteen or better in each of the four Grand Slam tournaments.

In July, Vaidisova went 2-0 during Czech Republic's 3-2 Fed Cup World Group Play-offs loss to France. She reached the semifinal on her debut in Stanford, losing 7-5, 6-2 to Kim Clijsters. Vaidisova reached her career-first Tier I semifinal in San Diego, losing to Clijsters again. After her success in San Diego, Vaidisova moved from No. 12 to No. 9, her career top 10 début, becoming the 12th-youngest player in Tour history to crack the Top 10, at 17 years, 3 months, and 2 weeks of age.

At the US Open, she made it to the third round, but lost to Jelena Jankovic, who later made it to the semifinal. In Beijing, she lost in the second round to Ai Sugiyama after a first round bye.

Vaidisova defeated Amelie Mauresmo for the second time at the Kremlin Cup in Moscow, after rallying from 1-6, 2-5 down and three match points, in their quarterfinal match. But Vaidisova lost to Nadia Petrova for a third time in their four meetings in the semifinal afterwards.

Nicole finished the year ranked #10, the first time she has ended the year in the top 10.